Summary
[...] with thousands of enzymes and different components, the UPS is highly specific when selecting targets- the family of ubiquitin ligases is the largest family of enzymes in eukaryotes. [...] the existence of a characterized ßTrCP binding motif would facilitate the identification of the novel substrates.
See the full content of this document
Extract
Tagged for Cleansing
I have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life.
With this need for order, I may have been better suited to be a physicist or a mathematician, but one of my high school teachers, Ugo Moncharmont, steered my fascination towards biology by showing me the rigor of scientific questioning in his field.It is somewhat ironic, in retrospect, that my adult research career began by studying phosphorylation, which is a fundamental, yet frustrating process to study experimentally. Kinases phosphorylate proteins when they transfer a phosphate group from a molecule of adenosine triphosphate (ATP) to an almost endless array of acceptor molecules. However, the changes are not always black and white because different degrees of phosphorylation provide diff...See the full content of this document
Sponsored links
