Summary
[...] in 2006, a research team led by University of Pennsylvania neuroscientists found TAR DNA-binding protein 43 (TDP43) lurking in the protinaceous inclusions that spider through the neurons of many ALS patients, as described in this month's Hot Paper.1 Discovered in 1995, TDP-43 had only been studied in the context of cystic fibrosis and HIV, not neurodegenerative diseases.
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Extract
A Potent Protein
Amyotrophic Lateral Sclerosis (ALS) is a deadly neurodegenerative disease characterized by a precipitous loss of motor neuron function. From the time researchers first named the disease, the key protein that either causes ALS or accumulates because of the disease remained a mystery.
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