Hydrating skin by stimulating biosynthesis of aquaporins.
Journal of Drugs in Dermatology › Vol. 6 Nbr. 6, June 2007
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Hydrating skin by stimulating biosynthesis of aquaporins.
Abstract
Aquaporins (AQPs) are proteins that facilitate the transport of water across cell membranes. AQP3 expression is related to the expressions of other epidermal proteins involved in water maintenance (ie, CD44, claudin-1, and filaggrin). The expressions of AQP3 water channels are strongly affected by age and chronic sun exposure, and a defective osmotic equilibrium could occur in the epidermis, which would account for the skin dryness observed in older people and skin areas most exposed to sunlight. We investigated active ingredients that are able to increase AQP3 levels in order to improve hydration in human skin keratinocytes. We selected an ethanolic/water (70/30 v/v) extract of Ajuga turkestanica, a plant from Central Asia, as the hydrating agent. After 17 days of treatment every 2 days with this extract (2.5 [micro]g/mL) in vitro, AQP3 exp...See the full content of this document
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