Summary
IN SEARCH OF CHANNELS What Jonas really wanted to do was look for calcium channels that she thought should be located in the membranes of the neurotransmitter-containing vesicles that pack within axon terminals awaiting the signal to dump their chemical load into the synapse. Together, she and Jonas have found that proteins known to be involved in regulating cell death form channels in the mitochondrial membranes of living cells, where they influence neuronal signaling, thus governing whether a synapse will be strengthened or removed.
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Extract
Channeling Neuroscience
Elizabeth Jonas grew up in a family that revolved around medicine. "My dad is a neurologist and I started to learn to read EEGs when I was 4," she says. "My parents wanted me to become a neurologist or some other type of physician." But Jonas had other plans. "Seeing my dad going to work in the morning and coming home at 11 o'clock at night, I started to think that medicine was not for me. Things came to a head in high school when I realized that I didn't like science. I really, really didn't like it."
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